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商品详细avanti极性脂质/单磷酸3-脱酰基脂质A(合成)专利号9241988/699852P-5mg
avanti极性脂质/单磷酸3-脱酰基脂质A(合成)专利号9241988/699852P-5mg
avanti极性脂质/单磷酸3-脱酰基脂质A(合成)专利号9241988/699852P-5mg
商品编号: 699852P-5mg
品牌: Avanti
市场价: ¥19736.00
美元价: 14790.00
产地: 美国(厂家直采)
公司:
产品分类:
公司分类: Sphingomyelin
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

699852 | 3D-PHAD®

Monophosphoryl 3-Deacyl Lipid A (Synthetic)Pat No. 9,241,988

3D-PHAD®
Info

3D-PHAD®

Monophosphoryl 3-Deacyl Lipid A (Synthetic)Pat No. 9,241,988

Vaccination is well-accepted as an effective method to prevent infections by mounting pathogen-specific immune responses prior to the infection. Usually, immunization with vaccine antigens alone is not able to induce robust or long-lasting immune responses — resulting in failure of protective immunity against infections. Thus, adjuvants are required to enhance cellular or humoral immune responses upon immunization. Because vaccine adjuvants using Lipid A have proven to be safe and effective in inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines, Avanti developed Phosphorylated HexaAcyl Disaccharide (PHAD®), the first fully synthetic monophosphoryl Lipid A available for use as an adjuvant in human vaccines.

The highly pure MPLA analog, 3D-PHAD®, provides a homogeneous synthetic equivalent for the 3-deacylated MPLA derived from bacterial LPS. While comparable to bacterial MPLA and other synthetic MPLA analogs at eliciting an immune response in a liposomal adjuvant system (see bar graph), 3D-PHAD® is less pyrogenic than its bacterial-derived mimic. Extensive preclinical testing with 3D-PHAD® demonstrated equivalency to PHAD®, and human trials have been scheduled for launch. 3D-PHAD® is protected under Pat No. 9,241,988. Licensing opportunities are available for vaccine or immunotherapy commercialization.

Stimulatory effect of PHAD®, 3D-PHAD®, and 3D(6-acyl)-PHAD® on macrophages. Macrophage cell line J774 cells were cultured with Avanti PHAD®, 3D-PHAD®, or 3D(6-acyl)-PHAD® for 24hrs. IL-12 levels in supernatants were measured by sandwich ELISA.

Adjuvant Activity

Antigen: gp140 from HIV-1

PHAD®, 3D-PHAD®, and 3D(6A)-PHAD® have been tested extensively in animals using a variety of antigens. In all cases, these adjuvants exhibit a similar activity and safety profile to bacterially-derived MPL. The data above demonstrate the equivalency of the three synthetic adjuvants to the bacterially-derived MPL when presented in a liposomal carrier system (DMPC/DMPG/Cholesterol).

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C82H158N3O20P
Percent Composition
C 64.07%, H 10.36%, N 2.73%, O 20.82%, P 2.02%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
1699735-79-9 CAS Registry Number is a Registered Trademark of the American Chemical Society
FormulaWeight
1537.114
Exact Mass
1536.118
Downloads
  • ChemDraw File
  • 3D Structure
  • Structure
  • Brochure
  • 699852 Adjuvant Data
  • Safety Data Sheet
References

Singh P, Matyas GR, Anderson A, Beck Z. Biophysical characterization of polydisperse liposomal adjuvant formulations. Biochem Biophys Res Commun. 2020 Aug 20;529(2):362-365. doi: 10.1016/j.bbrc.2020.05.156. Epub 2020 Jul 1. PMID: 32703436.

PubMed ID: 32703436

Martin ML, Bitzer AA, Schrader A, Bergmann-Leitner ES, Soto K, Zou X, Beck Z, Matyas GR, Dutta S. Comparison of immunogenicity and safety outcomes of a malaria vaccine FMP013/ALFQ in rhesus macaques (Macaca mulatta) of Indian and Chinese origin. Malar J. 2019 Nov 27;18(1):377. doi: 10.1186/s12936-019-3014-5.

PubMed ID: 31775762

Hernandez A, Luan L, Stothers CL, Patil NK, Fults JB, Fensterheim BA, Guo Y, Wang J, Sherwood ER, Bohannon JK. Phosphorylated Hexa-Acyl Disaccharides Augment Host Resistance Against Common Nosocomial Pathogens. Crit Care Med. 2019 Nov;47(11):e930-e938. doi: 10.1097/CCM.0000000000003967.

PubMed ID: 31567352

Beugeling M, De Zee J, Woerdenbag HJ, Frijlink HW, Wilschut JC, Hinrichs WLJ. Respiratory syncytial virus subunit vaccines based on the viral envelope glycoproteins intended for pregnant women and the elderly. Expert Rev Vaccines. 2019 Sep;18(9):935-950. doi: 10.1080/14760584.2019.1657013. Epub 2019 Aug 25.

PubMed ID: 31446807

Singh P, Bodycomb J, Travers B, Tatarkiewicz K, Travers S, Matyas GR, Beck Z. Particle size analyses of polydisperse liposome formulations with a novel multispectral advanced nanoparticle tracking technology. Int J Pharm. 2019 Jul 20;566:680-686. doi: 10.1016/j.ijpharm.2019.06.013. Epub 2019 Jun 6.

PubMed ID: 31176851

Smith RJ, Bryant RG. Metal substitutions incarbonic anhydrase: a halide ion probe study. Biochem Biophys Res Commun. 1975 Oct 27;66(4):1281-6.

PubMed ID: 31043512

Cawlfield A, Genito CJ, Beck Z, Bergmann-Leitner ES, Bitzer AA, Soto K, Zou X, Hadiwidjojo SH, Gerbasi RV, Mullins AB, Noe A, Waters NC, Alving CR, Matyas GR, Dutta S. Safety, toxicity and immunogenicity of a malaria vaccine based on the circumsporozoite protein (FMP013) with the adjuvant army liposome formulation containing QS21 (ALFQ). Vaccine. 2019 Jun 27;37(29):3793-3803. doi: 10.1016/j.vaccine.2019.05.059. Epub 2019 May 28.

PubMed ID: 31151801

Taleghani N, Bozorg A, Azimi A, Zamani H. Immunogenicity of HPV and HBV vaccines: adjuvanticity of synthetic analogs of monophosphoryl lipid A combined with aluminum hydroxide. APMIS. 2019 Mar;127(3):150-157. doi: 10.1111/apm.12927.

PubMed ID: 30746792
Certificates of Analysis
  • Certificate of Analysis(Lot No. 699852P-1MG-A-012and 5089PGA012)
  • Certificate of Analysis(Lot No. 699852P-5MG-A-012and 5089PHA012)
  • Certificate of Analysis(Lot No. 699852P-1MG-B-012and 5089PGB012)
  • Certificate of Analysis(Lot No. 699852P-5MG-B-012and 5089PHB012)
  • Certificate of Analysis(Lot No. 699852P-1MG-B-013and 5089PGB013)
  • Certificate of Analysis(Lot No. 699852P-5MG-A-013and 5089PHA013)
  • Certificate of Analysis(Lot No. 699852P-1MG-C-013and 5089PGC013)
  • Certificate of Analysis(Lot No. 699852P-1MG-D-013and 5089PGD013)
  • Certificate of Analysis(Lot No. 699852P-5MG-B-013and 5089PHB013)
  • Certificate of Analysis(Lot No. 699852P-5MG-C-013and 5089PHC013)
  • Certificate of Analysis(Lot No. 699852P-1MG-E-013and 5089PGE013)
  • Certificate of Analysis(Lot No. 699852P-5MG-G-013and 5089PHG013)
  • Certificate of Analysis(Lot No. 699852P-5MG-I-013and 5089PHI013)
  • Certificate of Analysis(Lot No. 699852P-5MG-H-013and 5089PHH013)
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品牌介绍
Avanti Polar Lipids 阿凡提极地脂质公司,有着50年的历史,创造了最高纯度的脂类产品。我们对高质量和独特的产品的热情只会被我们在市场上的良好声誉所超越。 Since its spartan beginnings in a 900 square foot rented laboratory space, Avanti has established a 25 acre manufacturing campus comprised of 11 buildings which house our manufacturing, formulation, analytical, and administrative units. Operations were moved to the current site in Alabaster, Alabama, in 1990, and we have continued to expand our capabilities and attract talented personnel to develop new and innovative products. With over 120 employees diligently working to provide high quality revolutionary lipid products, we have successfully grown our product offering to well over 2000 unique lipids, antibodies, and lipid research tools while maintaining the founding vision established by Dr. Shaw in 1967. Quite an accomplishment considering we started with a catalog containing only a handful of lipids isolated from plant and animal sources. 品牌 货号 名称 规格 Avanti Polar Lipids 860853 16:0 Azido Coenzyme A 1mg Avanti Polar Lipids 900415  Oleic Acid (18-azido) 5mg 25mg Avanti Polar Lipids 900414 16:0(alkyne)-18:1 PE 1mg 5mg Avanti Polar Lipids 900413 16:0(alkyne)-18:1 PC 1mg 5mg Avanti Polar Lipids 860831  C6(6-azido) Ceramide 5mg Avanti Polar Lipids 860832 C6(6-azido) LacCer 5mg Avanti Polar Lipids 860833  C6(6-azido) GalCer 5mg Avanti Polar Lipids 860834 C6(6-azido) GluCer 5mg Avanti Polar Lipids 900600 PhotoClick Sphingosine 100ug 250ug Avanti Polar Lipids 810340 Click PI(4,5)P2-azido 100ug Avanti Polar Lipids 900400 Palmitic acid (15-yne) 1mg 5mg Avanti Polar Lipids 900404 pacFA Ceramide 1mg Avanti Polar Lipids 900405 pacFA GlcCer 1mg Avanti Polar Lipids 900406 pacFA GalCer 1mg Avanti Polar Lipids 900407 16:0-pacFA PC 1mg