商品介绍
VPC 51299
(R,E)-(3-palmitamido-4-(4-((4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methoxy)phenyl)but-1-en-1-yl)phosphonic acid
VPC51299 is a potent low micromolar inhibitor containing a vinyl phosphonate head group and possessing a half-life of approximately 90 min in rats when dosed intravenously. Previously developed LPA1/LPA3 receptor antagonists contain a labile phosphate head group which impairs evaluation of scaffold LPA receptor antagonists in vivo. VPC51299 has replaced the phosphate with a more stable head group while retaining potency at both LPA1 and LPA3 to facilitate future in vivo studies of the biological functions of these receptors.Refer: J.E. East, et al. (2011). Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. Medchemcomm 2:325-330.
This product is covered by Patent Number US 8,283,339 B2. Avanti manufactures this under license from University of Virginia.
品牌介绍
Avanti Polar Lipids
阿凡提极地脂质公司，有着50年的历史，创造了最高纯度的脂类产品。我们对高质量和独特的产品的热情只会被我们在市场上的良好声誉所超越。
Since its spartan beginnings in a 900 square foot rented laboratory space, Avanti has established a 25 acre manufacturing campus comprised of 11 buildings which house our manufacturing, formulation, analytical, and administrative units. Operations were moved to the current site in Alabaster, Alabama, in 1990, and we have continued to expand our capabilities and attract talented personnel to develop new and innovative products. With over 120 employees diligently working to provide high quality revolutionary lipid products, we have successfully grown our product offering to well over 2000 unique lipids, antibodies, and lipid research tools while maintaining the founding vision established by Dr. Shaw in 1967. Quite an accomplishment considering we started with a catalog containing only a handful of lipids isolated from plant and animal sources.
品牌
货号
名称
规格
Avanti Polar Lipids
860853
16:0 Azido Coenzyme A
1mg
Avanti Polar Lipids
900415
Oleic Acid (18-azido)
5mg 25mg
Avanti Polar Lipids
900414
16:0(alkyne)-18:1 PE
1mg 5mg
Avanti Polar Lipids
900413
16:0(alkyne)-18:1 PC
1mg 5mg
Avanti Polar Lipids
860831
C6(6-azido) Ceramide
5mg
Avanti Polar Lipids
860832
C6(6-azido) LacCer
5mg
Avanti Polar Lipids
860833
C6(6-azido) GalCer
5mg
Avanti Polar Lipids
860834
C6(6-azido) GluCer
5mg
Avanti Polar Lipids
900600
PhotoClick Sphingosine
100ug 250ug
Avanti Polar Lipids
810340
Click PI(4,5)P2-azido
100ug
Avanti Polar Lipids
900400
Palmitic acid (15-yne)
1mg 5mg
Avanti Polar Lipids
900404
pacFA Ceramide
1mg
Avanti Polar Lipids
900405
pacFA GlcCer
1mg
Avanti Polar Lipids
900406
pacFA GalCer
1mg
Avanti Polar Lipids
900407
16:0-pacFA PC
1mg
