avanti polar lipids/1,2-diheptanoyl-sn-glycero-3-phosphocholine/1 x 200mg/850306P-200mg
商品编号：
850306P-200mg
品牌：
Avanti
市场价：
¥3680.00
美元价：
2760.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
07:0 PC (DHPC)
1,2-diheptanoyl-sn-glycero-3-phosphocholine
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC"s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis. Several of these products are manufactured under the current guidelines of Good Manufacturing Practice and are available for pharmaceutical use. If you have a requirement for a choline derivative not found on our list, please call us: custom synthesis is one of our specialties.
Preserve the Activity of Solubilized Membrane Proteins
Protein PreservationDHPC preserves the native conformation and therefore the activity of the solubilized proteins. The three dimensional structure and activity of proteins are retained not only at the 10-15mM DHPC concentrations at which maximum solubilization usually occurs, but also over a large range of DHPC concentrations (up to 40mM). Not only is the three dimensional structure and hence the activity of most protein retained in excess DHPC, but the proteins also appear to be stable in DHPC. Such a result suggests that the direct interaction of DHPC with integral membrane proteins is weak. If the interaction of DHPC with membrane proteins is indeed weak, it follows that intrinsic membrane lipids will remain associated with the membrane proteins.
Solubilization MechanismDHPC is thought to exert a wedge-like effect on the neighboring lipids, mainly due to its bulky polar group and short hydrocarbon chains. This produces membrane destabilization at relatively low DHPC concentrations. All membranes investigated are solubilized at an identical DHPC / lipid ratio. This finding is taken as evidence that DHPC primarily interacts with the lipid bilayer and not with the membrane proteins. The principle underlying the preservation of the native protein structure is the inability of DHPC to displace intrinsic membrane lipids from integral membrane proteins.
Advantages of DHPC
- DHPC preserves the activity of solubilized membrane proteins.
- DHPC is not readily oxidized, and is stable over a wide pH range (4-10).
- DHPC forms micelles rather than bilayers when dispersed in water. (CMC = 1.4mM)
- DHPC shows a broad size distribution depending on the NaCl concentration of suspension.
- DHPC does not interfere with spectrophotometric measurements.
- DHPC is an ultra pure compound.
品牌介绍
Avanti Polar Lipids
阿凡提极地脂质公司，有着50年的历史，创造了最高纯度的脂类产品。我们对高质量和独特的产品的热情只会被我们在市场上的良好声誉所超越。
Since its spartan beginnings in a 900 square foot rented laboratory space, Avanti has established a 25 acre manufacturing campus comprised of 11 buildings which house our manufacturing, formulation, analytical, and administrative units. Operations were moved to the current site in Alabaster, Alabama, in 1990, and we have continued to expand our capabilities and attract talented personnel to develop new and innovative products. With over 120 employees diligently working to provide high quality revolutionary lipid products, we have successfully grown our product offering to well over 2000 unique lipids, antibodies, and lipid research tools while maintaining the founding vision established by Dr. Shaw in 1967. Quite an accomplishment considering we started with a catalog containing only a handful of lipids isolated from plant and animal sources.
品牌
货号
名称
规格
Avanti Polar Lipids
860853
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品牌分类
Solvent Mixtures
阳离子脂质（转染）
Isoprenoids
极光® 金探针
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Enantiomers of Natural Lipids
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Headgroup Modified Lipids
脂肪酸修饰脂质
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辅酶A及其衍生物
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