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商品详细avanti polar lipids/22:0 Trehalose/5mg/890808P-5mg

avanti polar lipids/22:0 Trehalose/5mg/890808P-5mg

商品编号： 890808P-5mg

品牌： Avanti

市场价： ¥7104.00

美元价： 5325.00

产地：美国(厂家直采)

公司：

产品分类：多肽合成

公司分类： peptide

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

890808 | 22:0 Trehalose

D-(+)-trehalose 6,6"-dibehenate

Info

22:0 Trehalose

D-(+)-trehalose 6,6"-dibehenate

Incorporation of the glycolipid trehalose 6,6"-dibehenate (TDB) into cationic liposomes composed of the quaternary ammonium compound dimethyldioctadecylammonium (DDA) produce an adjuvant system which induces a powerful cell-mediated immune response and a strong antibody response, desirable for a high number of disease targets.

Data

Hygroscopic

Light Sensitive

Molecular Formula

C₅₆H₁₀₆O₁₃

Percent Composition

C 68.12%, H 10.82%, O 21.06%

Purity

>99%

Stability

1 Years

Storage Temperature

-20°C

CAS Number

66758-35-8 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

987.433

Exact Mass

986.763

Synonyms

TDB6,6'-didocosanoyl-α,α'-trehalose

Downloads

ChemDraw File
3D Structure
Structure
Brochure
Safety Data Sheet

References

Teng X, Tian M, Li J, Tan S, Yuan X, Yu Q, Jing Y, Zhang Z, Yue T, Zhou L, Fan X. Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine. Hum Vaccin Immunother. 2015;11(6):1456-64. doi: 10.1080/21645515.2015.1037057. PMID: 25905680; PMCID: PMC4514263.

PubMed ID: 25905680

Rose F, Wern JE, Ingvarsson PT, van de Weert M, Andersen P, Follmann F, Foged C. Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: A quality-by-design approach. J Control Release. 2015 Jul 28;210:48-57. doi: 10.1016/j.jconrel.2015.05.004. Epub 2015 May 6. PMID: 25957906.

PubMed ID: 25957906

Derrick SC, Yabe I, Morris S, Cowley S. Induction of Unconventional T Cells by a Mutant Mycobacterium bovis BCG Strain Formulated in Cationic Liposomes Correlates with Protection against Mycobacterium tuberculosis Infections of Immunocompromised Mice. Clin Vaccine Immunol. 2016 Jul 5;23(7):638-47. doi: 10.1128/CVI.00232-16. PMID: 27226281; PMCID: PMC4933783.

PubMed ID: 27226281

Larrouy-Maumus G, Layre E, Clark S, Prandi J, Rayner E, Lepore M, de Libero G, Williams A, Puzo G, Gilleron M. Protective efficacy of a lipid antigen vaccine in a guinea pig model of tuberculosis. Vaccine. 2017 Mar 7;35(10):1395-1402. doi: 10.1016/j.vaccine.2017.01.079. Epub 2017 Feb 9. PMID: 28190740.

PubMed ID: 28190740

Hansen M, Peltier J, Killy B, Amin B, Bodendorfer B, Härtlova A, Uebel S, Bosmann M, Hofmann J, Büttner C, Ekici AB, Kuttke M, Franzyk H, Foged C, Beer-Hammer S, Schabbauer G, Trost M, Lang R. Macrophage phosphoproteome analysis reveals MINCLE-dependent and -independent mycobacterial cord factor signaling. Mol Cell Proteomics. 2019 Jan 11. pii: mcp.RA118.000929. doi: 10.1074/mcp.RA118.000929. [Epub ahead of print]

PubMed ID: 30635358

Fomsgaard, A., Karlsson, I., Gram, G., Schou, C., Tang, S., Bang, P., Kromann, I., Andersen, P., Andreasen, L.V. (2011) Development and preclinical safety evaluation of a new therapeutic HIV-1 vaccine based on 18 T-cell minimal epitope peptides applying a novel cationic adjuvant CAF01. Vaccine. 29:7067-74.

PubMed ID: 21767590

Nordly, P., Agger, E.M., Andersen, P., Nielsen, H.M., Foged, C. (2011) Incorporation of the TLR4 agonist monophosphoryl lipid A into the bilayer of DDA/TDB liposomes: physico-chemical characterization and induction of CD8+ T-cell responses in vivo. Pharm Res. 28:553-62.

PubMed ID: 21042837

Gram, G.J., Karlsson, I., Agger, E.M., Andersen, P., Fomsgaard, A. (2009) A novel liposome-based adjuvant CAF01 for induction of CD8(+) cytotoxic T-lymphocytes (CTL) to HIV-1 minimal CTL peptides in HLA-A*0201 transgenic mice. PLoS One. 4:e6950.

PubMed ID: 19759892

Davidsen, J., Rosenkrands, I., Christensen, D., Vangala, A., Kirby, D., Perrie, Y., Agger, E.M., Andersen, P. (2005) Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6"-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses. Biochim Biophys Acta. 1718:22-31.

PubMed ID: 16321607

Certificates of Analysis

Certificate of Analysis(Lot No. 890808P-25MG-A-017and 6351PJA017)
Certificate of Analysis(Lot No. 890808P-5MG-A-017and 6351PHA017)
Certificate of Analysis(Lot No. 890808P-25MG-B-017and 6351PJB017)
Certificate of Analysis(Lot No. 890808P-5MG-B-017and 6351PHB017)
Certificate of Analysis(Lot No. 890808P-5MG-C-017and 6351PHC017)
Certificate of Analysis(Lot No. 890808P-25MG-C-017and 6351PJC017)
Certificate of Analysis(Lot No. 890808P-5MG-D-017and 6351PHD017)
Certificate of Analysis(Lot No. 890808P-5MG-E-017and 6351PHE017)
Certificate of Analysis(Lot No. 890808P-5MG-F-017and 6351PHF017)
Certificate of Analysis(Lot No. 890808P-25MG-D-017and 6351PJD017)

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品牌介绍

Avanti Polar Lipids 阿凡提极地脂质公司，有着50年的历史，创造了最高纯度的脂类产品。我们对高质量和独特的产品的热情只会被我们在市场上的良好声誉所超越。 Since its spartan beginnings in a 900 square foot rented laboratory space, Avanti has established a 25 acre manufacturing campus comprised of 11 buildings which house our manufacturing, formulation, analytical, and administrative units. Operations were moved to the current site in Alabaster, Alabama, in 1990, and we have continued to expand our capabilities and attract talented personnel to develop new and innovative products. With over 120 employees diligently working to provide high quality revolutionary lipid products, we have successfully grown our product offering to well over 2000 unique lipids, antibodies, and lipid research tools while maintaining the founding vision established by Dr. Shaw in 1967. Quite an accomplishment considering we started with a catalog containing only a handful of lipids isolated from plant and animal sources. 品牌货号名称规格 Avanti Polar Lipids 860853 16:0 Azido Coenzyme A 1mg Avanti Polar Lipids 900415 Oleic Acid (18-azido) 5mg 25mg Avanti Polar Lipids 900414 16:0(alkyne)-18:1 PE 1mg 5mg Avanti Polar Lipids 900413 16:0(alkyne)-18:1 PC 1mg 5mg Avanti Polar Lipids 860831 C6(6-azido) Ceramide 5mg Avanti Polar Lipids 860832 C6(6-azido) LacCer 5mg Avanti Polar Lipids 860833 C6(6-azido) GalCer 5mg Avanti Polar Lipids 860834 C6(6-azido) GluCer 5mg Avanti Polar Lipids 900600 PhotoClick Sphingosine 100ug 250ug Avanti Polar Lipids 810340 Click PI(4,5)P2-azido 100ug Avanti Polar Lipids 900400 Palmitic acid (15-yne) 1mg 5mg Avanti Polar Lipids 900404 pacFA Ceramide 1mg Avanti Polar Lipids 900405 pacFA GlcCer 1mg Avanti Polar Lipids 900406 pacFA GalCer 1mg Avanti Polar Lipids 900407 16:0-pacFA PC 1mg

公司介绍

品牌分类

Solvent Mixtures 阳离子脂质（转染） Isoprenoids 极光® 金探针 Bacterial Lipids Enantiomers of Natural Lipids Photoswitchable Lipids 新产品脂质试剂盒

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