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avanti polar lipids/MVL5/5mg/890000P-5mg

商品编号： 890000P-5mg

品牌： Avanti

市场价： ¥19135.00

美元价： 14340.00

产地：美国(厂家直采)

公司：

产品分类：其他

公司分类：

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

890000 | MVL5

N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide

Info

MVL5

N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide

New Multivalent Cationic Lipid for siRNA Delivery

• Improved total gene silencing• Lower non-specific gene silencing• Lower toxicity

These attributes establish the multivalent MVL5 as a superior transfection vector for siRNAs, and have implications for the optimal use of cationic lipids in therapeutic applications.

Now available as a pre-mixed kit, MVL5 and GMO ready to use.Avanti Number 640009

Data

Hygroscopic

Light Sensitive

Molecular Formula

C₅₉H₁₁₆Cl₅N₇O₄

Percent Composition

C 60.83%, H 10.04%, Cl 15.22%, N 8.42%, O 5.49%

Purity

>99%

Stability

1 Year

Storage Temperature

-20°C

CAS Number

464926-03-2 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

1164.862

Exact Mass

1161.754

Synonyms

N1,N1,N4-tris(3-ammoniopropyl)-5-((2-(3,4-bis((Z)-octadec-9-en-1-yloxy)benzamido)ethyl)amino)-5-oxopentane-1,4-diaminium chloride

Downloads

ChemDraw File
3D Structure
Structure
Safety Data Sheet

References

Ravi V, Madhankumar AB, Abraham T, Slagle-Webb B, Connor JR. Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms. PLoS One. 2019 Sep 6;14(9):e0221952. doi: 10.1371/journal.pone.0221952. eCollection 2019.

PubMed ID: 31491006

Guevara ML, Jilesen Z, Stojdl D, Persano S. Codelivery of mRNA with α-Galactosylceramide Using a New Lipopolyplex Formulation Induces a Strong Antitumor Response upon Intravenous Administration. ACS Omega. 2019 Aug 7;4(8):13015-13026. doi: 10.1021/acsomega.9b00489. eCollection 2019 Aug 20.

PubMed ID: 31460428

Chan CL, Ewert KK, Majzoub RN, Hwu YK, Liang KS, Leal C, Safinya CR. Optimizing cationic and neutral lipids for efficient gene delivery at high serum content. J Gene Med. 2014 Mar-Apr;16(3-4):84-96. doi: 10.1002/jgm.2762.

PubMed ID: 24753287

Leal C, Ewert KK, Shirazi RS, Bouxsein NF, Safinya CR. Nanogyroids incorporating multivalent lipids: enhanced membrane charge density and pore forming ability for gene silencing. Langmuir. 2011 Jun 21;27(12):7691-7. doi: 10.1021/la200679x. Epub 2011 May 25.

PubMed ID: 21612245

Bouxsein NF, McAllister CS, Ewert KK, Samuel CE, Safinya CR. Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA. Biochemistry. 2007 Apr 24;46(16):4785-92. Epub 2007 Mar 29.

PubMed ID: 17391006

Ewert K, Ahmad A, Evans HM, Schmidt HW, Safinya CR. Efficient synthesis and cell-transfection properties of a new multivalent cationic lipid for nonviral gene delivery. J Med Chem. 2002 Nov 7;45(23):5023-9.

PubMed ID: 12408712

Certificates of Analysis

Certificate of Analysis(Lot No. 890000P-1MG-A-010and 6343PGA010)
Certificate of Analysis(Lot No. 890000P-1MG-B-010and 6343PGB010)
Certificate of Analysis(Lot No. 890000P-1MG-D-010and 6343PGD010)
Certificate of Analysis(Lot No. 890000P-1MG-E-010and 6343PGE010)
Certificate of Analysis(Lot No. 890000P-10MG-A-010and 6343PIA010)
Certificate of Analysis(Lot No. 890000P-1MG-F-010and 6343PGF010)
Certificate of Analysis(Lot No. 890000P-1MG-G-010and 6343PGG010)
Certificate of Analysis(Lot No. 890000P-5MG-A-011and 6343PHA011)
Certificate of Analysis(Lot No. 890000P-5MG-A-012and 6343PHA012)

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品牌介绍

Avanti Polar Lipids 阿凡提极地脂质公司，有着50年的历史，创造了最高纯度的脂类产品。我们对高质量和独特的产品的热情只会被我们在市场上的良好声誉所超越。 Since its spartan beginnings in a 900 square foot rented laboratory space, Avanti has established a 25 acre manufacturing campus comprised of 11 buildings which house our manufacturing, formulation, analytical, and administrative units. Operations were moved to the current site in Alabaster, Alabama, in 1990, and we have continued to expand our capabilities and attract talented personnel to develop new and innovative products. With over 120 employees diligently working to provide high quality revolutionary lipid products, we have successfully grown our product offering to well over 2000 unique lipids, antibodies, and lipid research tools while maintaining the founding vision established by Dr. Shaw in 1967. Quite an accomplishment considering we started with a catalog containing only a handful of lipids isolated from plant and animal sources. 品牌货号名称规格 Avanti Polar Lipids 860853 16:0 Azido Coenzyme A 1mg Avanti Polar Lipids 900415 Oleic Acid (18-azido) 5mg 25mg Avanti Polar Lipids 900414 16:0(alkyne)-18:1 PE 1mg 5mg Avanti Polar Lipids 900413 16:0(alkyne)-18:1 PC 1mg 5mg Avanti Polar Lipids 860831 C6(6-azido) Ceramide 5mg Avanti Polar Lipids 860832 C6(6-azido) LacCer 5mg Avanti Polar Lipids 860833 C6(6-azido) GalCer 5mg Avanti Polar Lipids 860834 C6(6-azido) GluCer 5mg Avanti Polar Lipids 900600 PhotoClick Sphingosine 100ug 250ug Avanti Polar Lipids 810340 Click PI(4,5)P2-azido 100ug Avanti Polar Lipids 900400 Palmitic acid (15-yne) 1mg 5mg Avanti Polar Lipids 900404 pacFA Ceramide 1mg Avanti Polar Lipids 900405 pacFA GlcCer 1mg Avanti Polar Lipids 900406 pacFA GalCer 1mg Avanti Polar Lipids 900407 16:0-pacFA PC 1mg

公司介绍

品牌分类

Solvent Mixtures 阳离子脂质（转染） Isoprenoids 极光® 金探针 Bacterial Lipids Enantiomers of Natural Lipids Photoswitchable Lipids 新产品脂质试剂盒

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