700107 | Sitosterol (synthetic from plant sterol)
Sitosterol (synthetic from plant sterol)
Sitosterol (synthetic from plant sterol)
Sitosterol (synthetic from plant sterol)
β-sitosterol is a phytosterol (plant sterol) found in a wide variety of plants such as pecans, saw palmetto, avocados, pumpkin seed, rice bran, wheat germ, and soybeans. Recently, sitosterol has been investigated as a substitute for cholesterol in lipid-based mRNA delivery systems. In 2020, it was reported that β-sitosterol-substituted lipid nanoparticle (LNPs) maintained comparable size and encapsulation but were considerably more effective at mRNA transfection than LNPs containing cholesterol (Patel, 2020). Purchase Avanti"s sitosterol today to fuel your therapeutics delivery research.
C29H50O
C 83.99%, H 12.15%, O 3.86%
- ChemDraw File
- Structure
Patel S, Ashwanikumar N, Robinson E, Xia Y, Mihai C, Griffith JP 3rd, Hou S, Esposito AA, Ketova T, Welsher K, Joyal JL, Almarsson Ö, Sahay G. Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA. Nat Commun. 2020 Feb 20;11(1):983. doi: 10.1038/s41467-020-14527-2. Erratum in: Nat Commun. 2020 Jul 6;11(1):3435. PMID: 32080183; PMCID: PMC7033178.
- Certificate of Analysis(Lot No. 700107P-1G-A-010and 7071PQA010)
- Certificate of Analysis(Lot No. 700107P-100MG-A-010and 7071PLA010)
- Certificate of Analysis(Lot No. 700107 P 500 MG A 010and 7071 PPA010)
- Certificate of Analysis(Lot No. 700107 P 200 MG A 010and 7071 PNA010)
