avanti极性脂质/&α-半乳糖神经酰胺/1 x 1mg/867000P-1mg-免疫在线蚂蚁淘旗下平台

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商品详细avanti极性脂质/&α-半乳糖神经酰胺/1 x 1mg/867000P-1mg

avanti极性脂质/&α-半乳糖神经酰胺/1 x 1mg/867000P-1mg

商品编号： 867000P-1mg

品牌： Avanti

市场价： ¥6343.40

美元价： 4755.00

产地：美国(厂家直采)

公司：

产品分类：脂质体

公司分类： liposomes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

867000 | KRN7000

α-Galactosyl Ceramide

Info

KRN7000

α-Galactosyl Ceramide

KRN7000 is a synthetic analog of α-galactosylceramide and the marine natural product agelasphin. It is a specific ligand for human and mouse NKT cells and remains the best studied ligand of the lipid-binding MHC class I-like protein CD1d. KRN7000 protects against LPS-induced shock and displays potent antitumor activity in various in vivo models.

Data

Hygroscopic

Light Sensitive

Molecular Formula

C50H99NO9

Percent Composition

C 69.97%, H 11.63%, N 1.63%, O 16.78

Purity

>99%

Stability

1 Years

Storage Temperature

-20°C

CAS Number

158021-47-7 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

858.322

Exact Mass

857.732

Synonyms

αGalCer (2S,3S,4R)-1-O-(D-galactosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol

Downloads

ChemDraw File
3D Structure
Structure
Technical Data Sheet
Safety Data Sheet

References

Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, McLaughlin J, Cheng D, Hollis RP, Campo-Fernandez B, Urbinati F, Wei L, Pang L, Rezek V, Berent-Maoz B, Macabali MH, Gjertson D, Wang X, Galic Z, Kitchen SG, An DS, Hu-Lieskovan S, Kaplan-Lefko PJ, De Oliveira SN, Seet CS, Larson SM, Forman SJ, Heath JR, Zack JA, Crooks GM, Radu CG, Ribas A, Kohn DB, Witte ON, Yang L. Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell. 2019 Oct 3;25(4):542-557.e9. doi: 10.1016/j.stem.2019.08.004. Epub 2019 Sep 5.

PubMed ID: 31495780

Guevara ML, Jilesen Z, Stojdl D, Persano S. Codelivery of mRNA with α-Galactosylceramide Using a New Lipopolyplex Formulation Induces a Strong Antitumor Response upon Intravenous Administration. ACS Omega. 2019 Aug 7;4(8):13015-13026. doi: 10.1021/acsomega.9b00489. eCollection 2019 Aug 20.

PubMed ID: 31460428

Pereira CS, Pérez-Cabezas B, Ribeiro H, Maia ML, Cardoso MT, Dias AF, Azevedo O, Ferreira MF, Garcia P, Rodrigues E, Castro-Chaves P, Martins E, Aguiar P, Pineda M, Amraoui Y, Fecarotta S, Leão-Teles E, Deng S, Savage PB, Macedo MF. Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients. Front Immunol. 2019 Jun 4;10:1264. doi: 10.3389/fimmu.2019.01264. eCollection 2019.

PubMed ID: 31214199

Yu KKQ, Wilburn DB, Hackney JA, Darrah PA, Foulds KE, James CA, Smith MT, Jing L, Seder RA, Roederer M, Koelle DM, Swanson WJ, Seshadri C. Conservation of molecular and cellular phenotypes of invariant NKT cells between humans and non-human primates. Immunogenetics. 2019 May 23. doi: 10.1007/s00251-019-01118-9. [Epub ahead of print]

PubMed ID: 31123763

Lu Y, Zhong MC, Qian J, Calderon V, Cruz Tleugabulova M, Mallevaey T, Veillette A. SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection. Nat Immunol. 2019 Apr;20(4):447-457. doi: 10.1038/s41590-019-0334-0. Epub 2019 Mar 4.

PubMed ID: 30833791

Fuji N, Ueda Y, Fujiwara H, Toh T, Yoshimura T, Yamagishi H. Antitumor effect of alpha-galactosylceramide (KRN7000) on spontaneous hepatic metastases requires endogenous interleukin 12 in the liver. Clin Cancer Res. 2000 Aug;6(8):3380-7.

PubMed ID: 10955826

Protocols

Formulation for dissolving KRN7000:

Using pyrogen-free water, a solution is made of sucrose (57 mg/mL), L-histidine (7.5 mg/mL), and Tween 20 (5 mg/mL). The pH is adjusted to 7.2. KRN7000 is dissolved in a 10:1 (vol:vol) mixture of THF and methanol at a concentration of 1 mg/mL. The KRN7000 solution is added dropwise to the aqueous solution with constant stirring (20 µL KRN7000 solution per mL of aqueous solution). The resulting mixture is sonicated in a bath sonicator for 10 min and filter-sterilized.

Certificates of Analysis

Certificate of Analysis(Lot No. 867000P-1MG-A-013and 6153PGA013)
Certificate of Analysis(Lot No. 867000P-1MG-A-014and 6153PGA014)
Certificate of Analysis(Lot No. 867000P-1MG-B-014and 6153PGB014)
Certificate of Analysis(Lot No. 867000P-1MG-C-014and 6153PGC014)
Certificate of Analysis(Lot No. 867000P-1MG-A-015and 6153PGA015)
Certificate of Analysis(Lot No. 867000P-1MG-B-015and 6153PGB015)
Certificate of Analysis(Lot No. 867000P-1MG-A-016and 6153PGA016)
Certificate of Analysis(Lot No. 867000P-1MG-D-015and 6153PGD015)
Certificate of Analysis(Lot No. 867000P-1MG-E-015and 6153PGE015)

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品牌介绍

Avanti Polar Lipids 阿凡提极地脂质公司，有着50年的历史，创造了最高纯度的脂类产品。我们对高质量和独特的产品的热情只会被我们在市场上的良好声誉所超越。 Since its spartan beginnings in a 900 square foot rented laboratory space, Avanti has established a 25 acre manufacturing campus comprised of 11 buildings which house our manufacturing, formulation, analytical, and administrative units. Operations were moved to the current site in Alabaster, Alabama, in 1990, and we have continued to expand our capabilities and attract talented personnel to develop new and innovative products. With over 120 employees diligently working to provide high quality revolutionary lipid products, we have successfully grown our product offering to well over 2000 unique lipids, antibodies, and lipid research tools while maintaining the founding vision established by Dr. Shaw in 1967. Quite an accomplishment considering we started with a catalog containing only a handful of lipids isolated from plant and animal sources. 品牌货号名称规格 Avanti Polar Lipids 860853 16:0 Azido Coenzyme A 1mg Avanti Polar Lipids 900415 Oleic Acid (18-azido) 5mg 25mg Avanti Polar Lipids 900414 16:0(alkyne)-18:1 PE 1mg 5mg Avanti Polar Lipids 900413 16:0(alkyne)-18:1 PC 1mg 5mg Avanti Polar Lipids 860831 C6(6-azido) Ceramide 5mg Avanti Polar Lipids 860832 C6(6-azido) LacCer 5mg Avanti Polar Lipids 860833 C6(6-azido) GalCer 5mg Avanti Polar Lipids 860834 C6(6-azido) GluCer 5mg Avanti Polar Lipids 900600 PhotoClick Sphingosine 100ug 250ug Avanti Polar Lipids 810340 Click PI(4,5)P2-azido 100ug Avanti Polar Lipids 900400 Palmitic acid (15-yne) 1mg 5mg Avanti Polar Lipids 900404 pacFA Ceramide 1mg Avanti Polar Lipids 900405 pacFA GlcCer 1mg Avanti Polar Lipids 900406 pacFA GalCer 1mg Avanti Polar Lipids 900407 16:0-pacFA PC 1mg

公司介绍

品牌分类

Solvent Mixtures 阳离子脂质（转染） Isoprenoids 极光® 金探针 Bacterial Lipids Enantiomers of Natural Lipids Photoswitchable Lipids 新产品脂质试剂盒

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