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当前位置: 首页 > 产品中心 > Sterols > avanti polar lipids/2-acetyl-5-tetrahydroxybutyl imidazole/1 x 1mg/857393P-1mg
商品详细avanti polar lipids/2-acetyl-5-tetrahydroxybutyl imidazole/1 x 1mg/857393P-1mg
avanti polar lipids/2-acetyl-5-tetrahydroxybutyl imidazole/1 x 1mg/857393P-1mg
avanti polar lipids/2-acetyl-5-tetrahydroxybutyl imidazole/1 x 1mg/857393P-1mg
商品编号: 857393P-1mg
品牌: Avanti
市场价: ¥3684.00
美元价: 2763.00
产地: 美国(厂家直采)
公司:
产品分类: 固醇类
公司分类: Sterols
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
THI

THI

2-acetyl-5-tetrahydroxybutyl imidazole

Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase.1 Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 µg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs.1,2 The resulting lymphopenia is reversible following cessation of THI treatment.3 Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.4
1. Schwab, S.R., Pereira, J.P., Matloubian, M., et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309, 1735-1739 (2005).
2. Gugasyan, R., Coward, A., O’Connor, L., et al. Emigration of mature T cells from the thymus is inhibited by the imidazole-based compound 2-acetyl-4-tetrahydroxybutylimidazole. Immunology93, 398-404 (1998).
3. Bradbury, M.G., Doherty, K.V., Parish, C.R., et al. The immunosuppressive compound 2-acetyl-4-tetrahydroxybutyl imidazole inhibits the allogeneic mixed lymphocyte reaction by sequestration of a recirculating subpopulation of T cells. Immunology 87, 80-85 (1996).
4. Vogel, P., Donoviel, M.S., Read, R., et al. Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions.PLoS One 4(1), (2009).
品牌介绍
Avanti Polar Lipids 阿凡提极地脂质公司,有着50年的历史,创造了最高纯度的脂类产品。我们对高质量和独特的产品的热情只会被我们在市场上的良好声誉所超越。 Since its spartan beginnings in a 900 square foot rented laboratory space, Avanti has established a 25 acre manufacturing campus comprised of 11 buildings which house our manufacturing, formulation, analytical, and administrative units. Operations were moved to the current site in Alabaster, Alabama, in 1990, and we have continued to expand our capabilities and attract talented personnel to develop new and innovative products. With over 120 employees diligently working to provide high quality revolutionary lipid products, we have successfully grown our product offering to well over 2000 unique lipids, antibodies, and lipid research tools while maintaining the founding vision established by Dr. Shaw in 1967. Quite an accomplishment considering we started with a catalog containing only a handful of lipids isolated from plant and animal sources. 品牌 货号 名称 规格 Avanti Polar Lipids 860853 16:0 Azido Coenzyme A 1mg Avanti Polar Lipids 900415  Oleic Acid (18-azido) 5mg 25mg Avanti Polar Lipids 900414 16:0(alkyne)-18:1 PE 1mg 5mg Avanti Polar Lipids 900413 16:0(alkyne)-18:1 PC 1mg 5mg Avanti Polar Lipids 860831  C6(6-azido) Ceramide 5mg Avanti Polar Lipids 860832 C6(6-azido) LacCer 5mg Avanti Polar Lipids 860833  C6(6-azido) GalCer 5mg Avanti Polar Lipids 860834 C6(6-azido) GluCer 5mg Avanti Polar Lipids 900600 PhotoClick Sphingosine 100ug 250ug Avanti Polar Lipids 810340 Click PI(4,5)P2-azido 100ug Avanti Polar Lipids 900400 Palmitic acid (15-yne) 1mg 5mg Avanti Polar Lipids 900404 pacFA Ceramide 1mg Avanti Polar Lipids 900405 pacFA GlcCer 1mg Avanti Polar Lipids 900406 pacFA GalCer 1mg Avanti Polar Lipids 900407 16:0-pacFA PC 1mg